Neurokinin Receptor Antagonist

Neurokinin Receptor Antagonists (70):

Cat. No.	Product Name	Effect	Purity

HY-14407A

Fosaprepitant dimeglumine	Antagonist	98.02%
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-16346

Netupitant	Antagonist	99.93%
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-117216B

L-703606 oxalate hydrate	Antagonist	99.4%
L-703606 oxalate hydrate is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.

HY-P10619

[Tyr6,D-Phe7,D-His9]-Substance P (6-11)	Antagonist
[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin NK1 receptor antagonist that antagonizes Histamine (HY-B1204) induced hyperalgesia.

HY-105137

Lanepitant dihydrochloride	Antagonist
Lanepitant dihydrochloride (LY303870 dihydrochloride) is a non-peptide neurokinin-1 receptor antagonist. Lanepitant dihydrochloride has analgesic and anti-inflammatory activities.

HY-109171

Elinzanetant	Antagonist	98.36%
Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can improve vascular dilation and schizophrenia, and reduce levels of estradiol and progesterone.

HY-14432

Pavinetant	Antagonist	99.83%
Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

HY-18006

NKP608	Antagonist	99.88%
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.

HY-P1276A

Men 10376 TFA	Antagonist	98.95%
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-135108

QWF Peptide	Antagonist	98.10%
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM.

HY-16732

Tradipitant	Antagonist	99.66%
Tradipitant (VLY-686) is a neurokinin-1 (NK-1) antagonist.

HY-101704

Y1 receptor antagonist 1	Antagonist	99.69%
Y1 receptor antagonist 1 (H 409-22 isomer) is a neuropeptide Y1 receptor antagonist.

HY-16346S

Netupitant-d₆	Antagonist	99.56%
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-P1194A

Spantide I TFA	Antagonist	99.32%
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1278

GR 64349	Antagonist	99.45%
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-12114

Serlopitant	Antagonist
Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

HY-12142

Vofopitant	Antagonist	99.82%
Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively.

HY-14407

Fosaprepitant	Antagonist
Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-106659

SCH 900978	Antagonist
SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression.

HY-19456

SSR-241586	Antagonist
SSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS).

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